Hydrophilic Biopharmaceutical Pill Filter (PES)

Overview

The Hydrophilic Biopharmaceutical PES Pill Filter is a single-use, capsule-style membrane filter designed for critical biopharmaceutical applications where sterility, product integrity, and process reliability are essential. Featuring a hydrophilic Polyethersulfone (PES) membrane, it delivers high flow rates, low differential pressure, and low protein binding—ideal for filtering sensitive biologics and vaccine formulations.

The inherently hydrophilic PES membrane enables rapid wet-out and consistent performance without pre-wetting agents. Its disposable capsule design reduces contamination risk, eliminates cleaning validation, and supports integration into validated single-use systems across development, clinical, and commercial manufacturing.

Constructed with durable polypropylene housing and advanced filtration media, this filter offers excellent chemical compatibility, stable flow performance, and reliable operation in both dry and wet conditions—ensuring dependable, high-purity filtration in critical bioprocess workflows.

Performance is on par with Cobetter® and Pall® pill filters, offering comparable quality at a more economical cost.

⭐Key Attributes

• ⚙️ Processing Type: Filtration
• 💧 Productivity: 1000 L/Hour
• 💨 80psi/5.5 Bar
• 🔩 Core Component: Hydrophilic PES Membrane
  
• ⚖️ Weight: 0.7 kg
• 🧬 Low Protein Adsorption — Ideal for biotech, laboratory, and pharmaceutical use.
  
• 🧴 Excellent Compatibility — Suitable for corrosive liquids and organic compounds.
• 🔬 Absolute Filtration Rating
  Ensures precise particle retention and consistent filtration quality.
• Strong Chemical & Thermal Stability — PES exhibits excellent temperature tolerance and resistance to many common laboratory chemicals.
• ⚗️ Exceptional Chemical Compatibility
  Suitable for a wide range of aqueous solutions, including buffers, media, and biological fluids.
  
• 💧 Hydrophilic PES Membrane — Rapid wetting without pre-wetting and inherently low protein and drug binding for minimal sample loss.
• 🛡️ High-Purity Construction
  Hydrophilic membrane ensures fast wetting and stable flow rates. Engineered for sterile filtration with consistent pore size distribution and high microbial retention. Suitable for critical applications requiring low extractables and consistent integrity.
• 🚀 High Flow & Low Pressure Drop — Asymmetric pore structure maximizes membrane surface area for efficient throughput and reduced differential pressure.
  
• 💲 Economical Choice — Reliable performance at a lower cost than premium-name competitors. (purchase 300 get +50 for free-Promo code: Free50)

---

🏗️ Construction & Dimensions

• 🪶 Material: Polypropylene housing
• 🧱 Internal Support: PP or PP + stainless liner
• 🧱 Out Cage: PP
• 📏 Length Options: 2.5"
• 🫧 Pore Size Options: 0.10 μm, 0.22μm, 0.45 μm, 1 μm, 3 μm, 5 μm, 10 μm
• 📊 Effective Filtration Area: ≥ 0.60 m²

🌡️ Temperature & Pressure Ratings

• Normal Operating Temperature: ≤55°C
• Max Operating Temperature: 80°C (ΔP ≤ 0.10 MPa)
• Max Differential Pressure:
  ➤ Forward: 0.42 MPa @ 25°C
  ➤ Reverse: 0.21 MPa @ 25°C

🌟 Features & Benefits

• 🛡️ Ultra-Low Extractables
  High-quality core and cage materials, extremely low dissolved matter, maintaining product purity and stability.
• 🎛️ Flexible Filtration Options
  Available in single, double, and multi-layer membrane configurations, giving users more choices for performance, flow rate, and retention needs.
• 🔄 Universal Compatibility
  Multiple end-cap types allow seamless integration with a wide range of filter housings, making installation fast and versatile.
• 🔥 No Adhesive Contamination
  Thermally bonded construction eliminates the risk of adhesive pollutants, ensuring safe and clean filtration for sensitive applications.
  
• 🧼 Cleanroom Production Quality
  Manufactured in an ISO Class 8 cleanroom and rinsed with high-purity water, guaranteeing low particle shedding and high filtration integrity.
•  💰 Cost-effective; available in bulk packaging (purchase 300 get +50 for free-Promo code: Free50)
•  ✔️ 100% integrity tested during manufacturing
•  🔢 Individually serialized for full traceability

📋 Applications

🧫 Cell Culture & Media Processing

Recommended Micron Ratings: 0.45 µm / 0.22 µm / 0.10 µm

• Sterile filtration of cell culture media, buffers, and biological fluids to remove bacteria and particulates
• Preparation and sterilization of tissue culture media and viral suspensions
• Filtration of serum, antibiotics, and media supplements requiring high recovery and low adsorption
  

---

🧬 Biologics, Vaccines & Bioprocess Fluids

Recommended Micron Ratings: 0.45 µm / 0.22 µm / 0.10 µm

• Biologics and vaccine production for heat-sensitive pharmaceutical products
• Filtration of vaccines, antigens, and biological intermediates where thermal sterilization is not feasible
• Clarification and bioburden reduction of upstream and downstream bioprocess fluids
  

---

🦠 Microbiology & Life Sciences

Recommended Micron Ratings: 0.45 µm / 0.22 µm

• Microbiology and life-science fluid processing for sensitive biological samples
• Sterilization of diagnostic solutions, microbiological growth media, and laboratory reagents
• Processing of viral suspensions and microbial culture fluids
  

---

🧪 Laboratory, Diagnostic & Analytical Use

Recommended Micron Ratings: 0.45 µm / 0.22 µm

• Sample preparation for diagnostic assays and analytical testing
• Filtration of diagnostic buffers, reagents, and assay solutions to ensure reproducibility
  

---

🧠 Protein-Sensitive & Clinical Fluids

Recommended Micron Ratings: 0.22 µm / 0.10 µm

• Filtration of sensitive biological and clinical fluids where low protein binding is critical
• Ideal for applications requiring high product recovery, low extractables, and consistent flow performance. 

---

Filtration Stages & Recommended Micron Ratings

PES Biopharmaceutical Pill Filter

🧱 Pre-Filtration (Particulate Protection)

10 µm – 5 µm
Removes visible particulates and undissolved solids during raw material preparation and bulk solution handling. Protects downstream membranes and stabilizes bioprocess flow.

🧪 Clarification / Bioburden Reduction

3 µm – 1 µm – 0.45 µm
Reduces fine particulates and microbial load in buffers, media, and biological fluids prior to sterile filtration. Improves process efficiency and extends final filter life.

🛡️ Final Sterile Filtration (Sterilizing-Grade)

0.22 µm (industry standard)
Primary choice for sterile filtration of biologics, buffers, and process fluids. Commonly used for bacterial retention in aseptic biopharmaceutical manufacturing.

🔬 Enhanced Microbial Control

0.10 µm
Applied when increased microbial or mycoplasma control is required based on risk assessment, product sensitivity, or regulatory expectations.

Typical Biopharmaceutical Filtration Train

10 µm → 5 µm → 1 µm → 0.45 µm → 0.22 µm → 0.10 µm

⭐ Why Biopharmaceutical PES Membranes

⚗️ High Flow & Throughput Efficiency

The asymmetric pore structure of hydrophilic PES membranes supports high flow rates at low differential pressure, helping maintain process efficiency while minimizing shear stress on sensitive biological fluids.

🧠 Low Protein Binding

PES membranes exhibit low protein adsorption, making them well suited for protein-containing solutions such as serum, vaccines, biologics, and culture media, where product recovery is critical.

🛡️ Reliable Microbial Control

Biopharmaceutical-grade PES membranes are commonly available in sterilizing-grade pore sizes (e.g., 0.22 µm) and enhanced microbial control options (e.g., 0.10 µm) to support validated bacterial retention and risk-based microbial reduction strategies.

🧪 Broad Chemical Compatibility

Hydrophilic PES membranes demonstrate compatibility with a wide range of aqueous buffers, salts, alcohols, and process chemicals, supporting use across upstream, downstream, and final filtration steps.

🧬 Consistent Performance in Single-Use Systems

When integrated into pill-style (capsule) formats, PES membranes support closed, single-use processing, helping reduce cross-contamination risk, eliminate cleaning validation requirements, and simplify changeovers in GMP environments.

📋 Regulatory-Aligned Material Selection

Hydrophilic PES membranes are commonly manufactured to meet biopharmaceutical material expectations, with low extractables and leachables profiles and compatibility with integrity testing methods used in validated filtration processes.

❓ FAQ

 🔎 What are these capsule filters used for?

• The Hydrophilic PES Filter is designed for applications that require low protein adsorption, rapid wetting, and consistent flow performance. well-suited for biological, pharmaceutical, and chemical processes where maintaining sample integrity is essential. this cartridge effectively handles acidic, alkaline, and mildly corrosive solutions. Offering strong chemical resistance and a reliable filtration option for corrosive liquids, organic compounds, and a wide range of laboratory or production filtration needs.

 📌 Which micron size should I choose?

• 10 µm – Standard filtration
• 5 µm – Fine filtration
• 3 µm – Coarse pre-filtration
• 1 µm – Pre-filtration / particle reduction
• 0.45 µm – Fine particulate filtration
• 0.22 µm – Sterile-grade filtration
• 0.10 µm – Ultra-fine sterile filtration

 🧰 Which connection type should I select?

• CPC – Quick-connect
• Swagelok – Precision compression fittings
• Hose Barb – Flexible tubing
• 1/4" NPT

 ♻️ Are these reusable?

• No. These are single-use filters.

 🔥 Can they handle hot liquids or gases?

• Yes, up to 60°C. / 140F°

💎 Why Choose Filter Forge Supply

• 🏭 Built and tested in the United States
• 📄 ISO Certified manufacturing process
• 🚚 Fast delivery