Overview

The PES Pharmaceutical Capsule Filter is a single-use, capsule-style membrane filter designed for critical pharmaceutical filtration, including biologics and vaccine production, where microbial control, product integrity, and process reliability are essential. It utilizes a hydrophilic Polyethersulfone (PES) membrane to deliver high flow rates, low differential pressure, and low protein adsorption, making it ideal for sterile and high-purity liquid applications. The disposable capsule design reduces contamination risk, eliminates cleaning validation, and supports validated single-use systems across development, clinical, and commercial manufacturing. Built with durable polypropylene housing and advanced filtration media, the filter provides consistent flow, strong chemical resistance, and reliable performance in both dry and moist conditions, ensuring dependable high-purity filtration where precision matters.

Performance is on par with Cobetter® and Pall® capsule filters, offering comparable quality at a more economical cost.

⭐Key Attributes

• ⚙️ Processing Type: Filtration
• 💧 Productivity: 1000 L/Hour
• 💨 80psi/5.5 Bar
• 🔩 Core Component: Hydrophilic PES Membrane
  
• ⚖️ Weight: 0.5 kg
• 🧬 Low Protein Adsorption — Ideal for biotech, laboratory, and pharmaceutical use.
  
• 🧴 Excellent Compatibility — Suitable for corrosive liquids and organic compounds.
• 🔬 Absolute Filtration Rating
  Ensures precise particle retention and consistent filtration quality.
• Strong Chemical & Thermal Stability — PES exhibits excellent temperature tolerance and resistance to many common laboratory chemicals.
• ⚗️ Exceptional Chemical Compatibility
  Suitable for a wide range of aqueous solutions, including buffers, media, and biological fluids.
  
• 💧 Hydrophilic PES Membrane — Rapid wetting without pre-wetting and inherently low protein and drug binding for minimal sample loss.
• 🛡️ High-Purity Construction
  Hydrophilic membrane ensures fast wetting and stable flow rates. Engineered for sterile filtration with consistent pore size distribution and high microbial retention. Suitable for critical applications requiring low extractables and consistent integrity.
• 🚀 High Flow & Low Pressure Drop — Asymmetric pore structure maximizes membrane surface area for efficient throughput and reduced differential pressure.
  
• 💲 Economical Choice — Reliable performance at a lower cost than premium-name competitors. (purchase 300 get +50 for free-Promo code: Free50)

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🏗️ Construction & Dimensions

• 🪶 Material: Polypropylene housing
• 🧱 Internal Support: PP or PP + stainless liner
• 🧱 Out Cage: PP
• 📏 Length Options: 3.94", 5", 7.5", 10", 20"
• 🫧 Pore Size Options: 0.10 μm, 0.22μm, 0.45 μm, 1 μm, 3 μm, 5 μm
• 📊 Effective Filtration Area: ≥ 0.60 m²

🌡️ Temperature & Pressure Ratings

• Normal Operating Temperature: ≤55°C
• Max Operating Temperature: 80°C (ΔP ≤ 0.10 MPa)
• Max Differential Pressure:
  ➤ Forward: 0.42 MPa @ 25°C
  ➤ Reverse: 0.21 MPa @ 25°C

🌟 Features & Benefits

• 🛡️ Ultra-Low Extractables
  High-quality core and cage materials, extremely low dissolved matter, maintaining product purity and stability.
• 🎛️ Flexible Filtration Options
  Available in single, double, and multi-layer membrane configurations, giving users more choices for performance, flow rate, and retention needs.
• 🔄 Universal Compatibility
  Multiple end-cap types allow seamless integration with a wide range of filter housings, making installation fast and versatile.
• 🔥 No Adhesive Contamination
  Thermally bonded construction eliminates the risk of adhesive pollutants, ensuring safe and clean filtration for sensitive applications.
  
• 🧼 Cleanroom Production Quality
  Manufactured in an ISO Class 8 cleanroom and rinsed with high-purity water, guaranteeing low particle shedding and high filtration integrity.
•  💰 Cost-effective; available in bulk packaging (purchase 200 get +50 for free-Promo code: Free50)
•  ✔️ 100% integrity tested during manufacturing
•  🔢 Individually serialized for full traceability

📋 Applications

💊 Pharmaceutical Manufacturing 

Suitable Micron Ratings: 5.0 µm / 3.0 µm / 1.0 µm / 0.45 µm / 0.22 µm / 0.10 µm

Engineered for critical liquid filtration throughout pharmaceutical production, PES pill filters support high-purity processing, contamination control, and regulatory compliance. Their low extractables and hydrophilic membrane chemistry make them ideal for validated processes requiring consistent and reproducible filtration performance. 

💉 Final Sterile Filtration

Suitable Micron Ratings: 0.22 µm (standard) / 0.10 µm (enhanced control)

Designed for terminal sterilizing filtration of injectables, ophthalmic solutions, and liquid drug products.

• Commonly utilized at 0.22 µm (and 0.10 µm where required) for reliable bacterial retention
  
• Maintains high flow rates with low differential pressure, protecting sensitive formulations
  
• Supports aseptic filling and final product integrity prior to packaging
• 0.22 µm – Industry standard for bacterial retention and aseptic processing
  
• 0.10 µm – Used where enhanced microbial or mycoplasma control is required
  Ensures product sterility prior to aseptic filling and final packaging.

🚿 Water for Injection (WFI) & Utility Filtration

Suitable Micron Ratings: 0.45 µm / 0.22 µm

Optimized for filtration of WFI, purified water, and pharmaceutical utilities, including:

• Pre-use and point-of-use WFI filtration
•  CIP/SIP rinse water and cleaning solution filtration
  
•  Removal of particulates and microbial contaminants in validated water systems
  PES membranes offer excellent thermal stability and wetting characteristics, ensuring dependable performance during repeated sterilization cycles.
• 0.45 µm – Particulate control and system protection
• 0.22 µm – Point-of-use microbial control
  PES membranes maintain consistent performance under thermal and chemical exposure common in pharmaceutical water systems.

🧬 Biologics & Vaccine Production

Suitable Micron Ratings: 0.45 µm / 0.22 µm / 0.10 µm

Ideal for heat-sensitive biologics, vaccines, and protein-based formulations where product integrity is critical.

• Low protein binding minimizes active ingredient loss
  
• High flow capacity supports upstream and downstream processing
  
• Compatible with buffers, media, and intermediates used in biologics manufacturing
  
• Supports scalable single-use processing platforms                                                         
• 0.45 µm – Clarification and pre-filtration
  
• 0.22 µm – Bioburden reduction and sterile filtration
  
• 0.10 µm – Enhanced microbial control for critical biologic applications
  Low protein binding PES membranes help preserve yield and biological activity.

🧪 Process Development & Single-Use Systems

Suitable Micron Ratings: 5.0 µm → 0.10 µm (application dependent)

Frequently integrated into R&D, clinical trials, and commercial single-use assemblies, reducing contamination risk while eliminating cleaning validation. Disposable PES pill filters enhance operational efficiency and simplify changeovers in multi-product facilities.

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Filtration Stages & Recommended Micron Ratings

PES Pharmaceutical Capsule Filter

🧱 Pre-Filtration (Particulate Protection)

10 µm – 5 µm
Removes visible particulates and insoluble debris during raw material handling and bulk solution preparation. Protects downstream membranes and improves overall filtration efficiency.

🧪 Clarification / Bioburden Reduction

3 µm – 1 µm – 0.45 µm
Reduces fine particulates and microbial load prior to sterile filtration. Enhances process consistency, extends final filter life, and supports validated filtration trains.

🛡️ Final Sterile Filtration (Sterilizing-Grade)

0.22 µm (industry standard)
Primary choice for terminal sterile filtration of pharmaceutical liquids, buffers, and aqueous drug products. Commonly specified for reliable bacterial retention and aseptic processing.

🔬 Enhanced Microbial Control

0.10 µm
Used in applications requiring increased microbial or mycoplasma control based on process risk assessment or regulatory expectations.

Typical Pharmaceutical Filtration Train

10 µm → 5 µm → 1 µm → 0.45 µm → 0.22 µm → 0.10 µm

⭐ Why Hydrophilic PES Membranes

• 💧 Naturally hydrophilic – no pre-wetting required
• 🧬 Low protein binding preserves valuable biomolecules
• 🚀 High flow rates with uniform pore structure
• 🛡️ Excellent chemical compatibility and durability

❓ FAQ

 🔎 What are these capsule filters used for?

• The Hydrophilic PVDF Capsule Filter is designed for applications that require low protein adsorption, rapid wetting, and consistent flow performance. well-suited for biological, pharmaceutical, and chemical processes where maintaining sample integrity is essential. this cartridge effectively handles acidic, alkaline, and mildly corrosive solutions. Offering strong chemical resistance and a reliable filtration option for corrosive liquids, organic compounds, and a wide range of laboratory or production filtration needs.

 📌 Which micron size should I choose?

• 10 µm – Standard filtration
• 5 µm – Fine filtration
• 3 µm – Coarse pre-filtration
• 1 µm – Pre-filtration / particle reduction
• 0.45 µm – Fine particulate filtration
• 0.22 µm – Sterile-grade filtration
• 0.10 µm – Ultra-fine sterile filtration

 🧰 Which connection type should I select?

• CPC – Quick-connect
• Swagelok – Precision compression fittings
• Hose Barb – Flexible tubing
• 1/4" NPT

 ♻️ Are these reusable?

• No. These are single-use filters.

 🔥 Can they handle hot liquids or gases?

• Yes, up to 60°C. / 140F°

💎 Why Choose Filter Forge Supply

• 🏭 Built and tested in the United States
• 📄 ISO Certified manufacturing process
• 🚚 Fast delivery